Volume-1, Issue-2

1. Article ID. 0008 : Launching of the Volume-1, Issue-2 of International Journal of Medical, Pharmaceutical and Biological Sciences

Author: Anjali Pawar

Abstract: I am very happy to introduce Issue-2, Volume-1 of an online e-journal entitled, “International Journal of Medical, Pharmaceutical and Biological Sciences (IJMPBS)”, Which is a peer reviewed and subscription free open access journal. This issue comprises of one research and three review articles. This issue covers information from the different areas like pharmaceutical chemistry, Traditional System of Medicines, Pharmacognosy & Phytochemistry. A research paper has provided a detailed insight about computation of drug efficacy indices of ayurvedic and herbal formulation. The present issue also discusses about repurposing of thioridazines as an anticancer drug, Unani system of medicine and various beauty plants of Indian origin.

Keywords: IJMPBS, Editorial, July-September 2021 issue.

2. Article ID. 0009 : Progress In Development of Herbal Cosmeceuticals: Current Status and Prospects

Authors: Anuja S. Motule, Prajakta N. Dongare, Manisha P. More, Minakshee G. Nimbalwar, Sagar S. Mankar, Jagdish V. Manwar, Ravindra L. Bakal

Abstract: Now a days, use of herbal cosmetic preparations is going on increasing across the world. This might be due to its more aesthetic value and lesser or without side effects. The active chemical constituents present in plants are responsible for their beauty effects. Since the ancient time, most of the plants are being used for increasing the appearance of person. In traditional medicine system, there is report of more than 1000 such types of herbs that are being used in the preparation of many beauty products. These products possess advantages such as economic, easy availability, and widely acceptance by peoples. Personal skin care products are in huge demand due to the growing consumer awareness about natural ingredients. They are formulated by using different herbs to make the base in which one or more herbal ingredients are used to cure various skin diseases or disorders. In present paper, we have covered utmost information about various herbs and plants used in cosmeceuticals.

Keywords : Medicinal plants; Cosmeceuticals; Aloe vera; Antioxidant; Anti-aging.

3. Article ID. 0010 : Repurposing of Thioridazine as Anticancer Agent: An Overview

Authors: Reena Ghumare, Gracy Mascaranace, Nishant Khatri, Tanuja Masane

Abstract: Thioridazine was an antipsychotic drug which was widely used to treat schizophrenia and psychosis but had been abandoned due to its cardio-toxic effect including arrhythmia. Some years back, it was analyzed that the patients under its treatment showed significantly lower risk of getting cancer (-1.04%). The study for various types of cancer including Glioblastoma, Hepatocellular carcinoma, Breast Cancer, Gastric cancer, Esophageal Cancer, Colon Cancer with on-going experiments has been practiced. The prevalence and dose-dependent effect was also studied for investigating the adverse drug effects as well as any toxicological conditions. Thioridazine has been used as a combination adjuvant alongside many drugs. The clinical results were reported with its mechanism and the pharmacology as well. In this review, we summarize the recent studies on anticancer activities of Thioridazine and studies for further advancements.

Keywords : Thioridazine, Glioblastoma, Hepatocellular carcinoma, Breast Cancer, Gastric cancer, Esophageal Cancer.

4. Article ID. 0011 : Comparison of the Computed Drug Efficacy Indices [Q(Vpk)] of Ayush-64 and Coronil Tablets

Authors: Abhilash Mullasseril

Abstract: The COVID-19 pandemic is still continuing as a completely unresolvable problem in front of the scientific community that needs an effective scientific solution even though some vaccines were invented and developed in a short span of research. The scientific community is keenly observing to prove those vaccines for their complete therapeutic effects. It is also worthwhile to discuss about the two major drug formulations viz. Ayush-64 and Coronil Tablets that are formulated for improving the health conditions. The respective ingredients of these herbal formulations were critically studied based on the classical texts and computed the therapeutic effects in terms of Tridoshas the three somatic humours, the very fundamental principle of Ayurveda. Finally, the Drug Efficacy Indices [Q(VPK)] of those two formulations were computed, compared and reported.

Keywords: The Drug Efficacy Index [Q(VPK)], CORONIL, AYUSH-64, COVID-19, Ayurveda, Herbal Formulations.

5. Article ID. 0012 : Ethnomedicinal, Phytochemical and Cosmeceutical Updates on Beauty Plants from Indian Origin

Authors: Prerna A. Patinge, Prajakta N. Dongare, Manisha P. More, Jagdish V. Manwar, Shivrani W. Nimbokar, Ravindra L. Bakal

Abstract: Herbal cosmetics are prepared from various herbs or their extracts. Since ancient period, India is a mother land of herbal cosmetics. Day-by-day, demand and use of such preparations is going on increasing across the world. Today, they are considered as invaluable gift of nature. Traditional Indian medicine system is based on incorporation of plants, parts thereof or extracts for the increasing the appearance of the peoples. Despite the availability of thousands of artificial beauty products (cosmetics), most of the peoples still believes in the use of herbal products. Indian herbal beauty products are popular in the world for their quality and safety. Herbs and spices have been used in maintaining and enhancing human beauty since time immemorial. In the present paper, we have covered the utmost information related to the potential and cosmeceutical applications of beauty plants from Indian origin.

Keywords : Herbs; Beauty; Indian; Cosmeceutical; Tulsi; Haldi; Rose.

6. Article ID. 0013 : Unani System of Medicine – An Overview

Authors: Shirin Shaikh, Harshal Ashok Pawar

Abstract: Unani system of medicine is one of the oldest systems which was originated in Greece by Hippocrates. According to this system human body is composed of the four basic elements like earth, water, air, fire and the body fluid is composed of blood, phlegm, yellow bile, black bile. Also, it talks about four temperaments. Bringing about harmony among the disturbance in the above is the aim of treatment. Unani medicine believes in the promotion of health, prevention of diseases through various modes of treatment i.e., regimental therapy, diet therapy, pharmacotherapy, surgery. It has been using the drugs of herbal, animal and mineral origin. Government of India established a Central Council for Research in Unani Medicine to develop this system in its own theoretical framework. This review gives an overview of unani system of medicine.

Keywords : Unani, Cupping, System of Medicine.

7. Article ID. 0014 : Ethosomes: A Revolutionary Trend In Lipid Based Vesicles And Particulate Carriers For Transdermal Delivery Of Drugs

Authors: Samruddhi S. Kukade, Minakshee G. Nimbalwar, Wrushali A. Panchale, Ravindra L. Bakal, Bhushan R. Gudalwar, Jagdish V. Manwar

Abstract: In recent years, transdermal drug delivery systems have acquired a lot of attention of researchers across the world. Encapsulation of the drug in ethanol-based lipid carrier like ethosomes has been widely recognized as one of the simple and convenient approach to accomplish the permeation of drug via skin. These are non-invasive particulate transporter that reaches drug in deep skin layers and the systemic circulation. Over the liposomes, ethosomes have higher penetration rate through the skin. The increased permeation of ethosomes is apparently due to the presence of ethanolic content in it. Basically, ethosomes are composed of phospholipids, ethanol and water. Ethosomes come up with a number of advantages including improved drug delivery, efficacy, patient compliance and easement. This review focuses on the various aspects of ethosomes likes excipients various method of preparation, characterization, applications, patent reports and future prospects.

Keywords : Ethosomes, Particulate carrier, Vesicle, Transdermal.

8. Article ID. 0015 : Microbeads: Generation, Threat To Biological And Ecological Systems And Use Of Natural Alternatives

Authors: Wrushali A. Panchale, Jagdish V. Manwar, Minakshee G. Nimbalwar, Ashish B. Wadekar, Iftekhar Ahmed, Ravindra L. Bakal

Abstract: Microbeads are solid plastic particles which are less than 1 mm in size and added to personal care products such as soap, facial scrub and toothpaste as exfoliating agents mainly to remove dead cells from the skin. They are often added as an exfoliant or application enhancer in personal care products such as rinse off cosmetics, and cleaning products. The over use of plastic results in accumulation of plastic waste in our ecosystems. They are not captured by most of the waste water treatment systems. Now a days, various countries started to ban microbeads for avoiding possible hazards and future consequences related to ecosystem. In present work, we have covered details of sources of microbeads, their toxic effects on biological and ecological system, precautions to be taken and finding of alternatives for microbeads.

Keywords : Microbeads; Microparticle; Cosmetics; Human; Ecosystem.