Volume-1, Issue-3

1. Article ID. 0016 : Launching of the Volume-1, Issue-3 of International Journal of Medical, Pharmaceutical and Biological Sciences

Author: Anjali Pawar

Abstract: I am very happy to announce Issue-3, Volume-1 of an online e-journal entitled, “International Journal of Medical, Pharmaceutical and Biological Sciences (IJMPBS)”, Which is a peer reviewed and subscription free open access journal. This issue comprises of one research and three review articles. This issue covers information from the different areas like pharmaceutics, Novel drug delivery system, Traditional System of Medicines, and a Clinical study. A research paper has provided a detailed insight about cementing capacity of an herb, Centella asiatica, in hip bone replaced patient. The present issue discusses about strategies involved in the development of novel drug delivery systems such as Liposomes and Niosomes. This issue also provides detailed overview about an emerging Electro-homeopathic system of medicines.

Keywords: IJMPBS, Editorial, October-December 2021 issue.

2. Article ID. 0017 : Physicochemical Properties and Targeting Strategies For Liposomes: A Versatile Drug Delivery System

Authors: Minakshee G. Nimbalwar, Bhushan R. Gudalwar, Anuja S. Motule, Shivam A. Bartere, Smita S. Sapate, Jagdish V. Manwar* and Ravindra L. Bakal

Abstract: Liposomes are phospholipid-based bilayer vesicular systems. It can encapsulate both hydrophilic and hydrophobic drugs. Its properties like biocompatibility and site-specific action are the two most attractive features of the systems. Their architecture has been satisfactorily accepting a great technical advance such as remote drug loading, combining passive, active drug targeting concepts, etc. It can be used in diverse areas like carrier for anticancer, bio-active molecules, diagnostics, and therapeutic agents. In present review, we discuss in detailed about structure of liposomes and liposomes as effective targeting delivery system.

Keywords : Liposomes; Vesicle; Physicochemistry; Targeting site.

3. Article ID. 0018 : The Cementing Capacity of Centella Asiatica in Hip Bone Replaced Case: A Clinical Study

Authors: K J Abraham, Kaniyanthara, Muttom PO, Haripad, Kerala

Abstract: The folk medicine shows its miraculous power some times over the other systems of medicine. The process of healing completely the bone fracture takes many months to years and may even leave the gaps within and around the fracture due to inadequate deposits due to the lack of calcium and phosphorous metals. This happens commonly during the treatment of fractures occurred in elderly people and people those who are anaemic in nature. Here the fracture occurred below the ball of femur and considerably large gap was created. The juice of Centella asiatica (belongs to Apiaceae or Umbelliferae family) commonly known as Kudangal in local language along with various combinations of dairy products and honey cured the gap completely. The plant is having many medicinal values in addition to its culinary use as evident from many sources. It is found rich in various amino acids like aspartic acid, glycine, glutamic acid, phenylalanine etc and in addition to them the ash of the plant contains many chlorides, sulphates, phosphates and metals like iron, calcium, magnesium, sodium etc. that may have many proven biological effects.

Keywords : Centella asiatica, Gap in fractures, Calcium supplements, Honey, Swarasa, Alternative Systems of Medicine.

4. Article ID. 0019 : Electro-homeopathy : An Emerging Approach In Therapeutics

Authors: Anjali Harshal Pawar, Harshal Ashok Pawar*

Abstract: Spagyric Homeopathy or Electro homoeopathy is an art of healing through alchemical herbal extracts, based on the principle, Life is in the Blood and Lymph and disease in its Vitiations. Electro homeopathic drugs are composed entirely of components obtained from herbal/medicinal plants and are manufactured with purified water and a sophisticated process of extracting spagyric essence from medicinal plants at room temperature. Electro homeopathy is a drug system that is used to treat a range of diseases and ailments. The concept of electro-homeopathy is that more than one of the organs involved or affected by the condition occurs when disease occurs in the body, because the entire body is interconnected and very complex as well. Electro Homoeopathy is a plant-orientated system of herbal medicine. It is a part of alternative system of medicine. It cures all kind of diseases rapidly without creating any side effects. Electro homoeopathy medicine have removed certain pain with quick like electricity when prescribed internally. External prescription of this medicines is based on law of polarity. It also relieves pain magically due to its influence on nervous system. The present review article gives an overview about an emerging Electro homeopathic therapy.

Keywords : Electro homoeopathy, Cohobation process, Concept of electricity, Temperament.

5. Article ID. 0020 : Recent Developments in Niosomes : A Smarter Vesicular Drug Delivery System

Authors: Minakshee G. Nimbalwar, Shrutika S. Deshmukh, Anuja S. Motule, Bhushan R. Gudalwar, Jagdish V. Manwar*, Ravindra L. Bakal

Abstract: In the field of nanotechnology, researchers have shown an optimistic progress in the development of novel dosage forms. Niosomes are one of the novel dosage forms which overcome limitations associated with other vesicular drug delivery systems. They are the non-ionic surfactant-based vesicle formed by self-association in an aqueous phase. It is mainly designed to delivery of drug to the targeted site, release of drug by controlled manner, in skin disorders, viral infection, microbial illnesses, in diagnostic imaging, as a vaccine adjuvant, etc. There are several factors which affect the niosomal vesicle formation like the type of surfactant, method of preparation, temperature. This review focuses on the basic details of niosomes, additives for formulation of niosomes, types of niosomes, factors affecting on niosomes, methods of preparation, characterization of niosome, applications, recent researches in niosomes and published patents on niosomes.

Keywords : Niosomes; Non-ionic surfactants; Vesicles; Controlled delivery.